Whole Genome Sequencing (WGS) is the most comprehensive genetic test – it analyzes virtually your entire genome. It enables the detection of genetic variants that may be associated with inherited predispositions to certain diseases, responses to selected medications (pharmacogenetics), or carrier status for some hereditary conditions.
At ComfortLab, we emphasize high-quality laboratory practice and interpretation of results in the context of current scientific knowledge – including comparison with reference data from the Czech population, which we have created and to which we have full access (www.czechgenome.cz). The result is a clear report that you will receive electronically in a secure results portal.
Who the test is suitable for
The test may be useful if, for example:
- you want the most comprehensive overview of your genetic predispositions (prevention, lifestyle, long-term planning),
- there is a history of certain diseases in your family at a younger age (e.g., selected cancers, cardiomyopathies, sudden deaths) and you want to consider genetic clarification,
- you are planning a family and are interested in carrier status for selected genetically determined conditions,
- you are taking (or may take) certain medications and want to know the genetic factors that may affect their effectiveness or risk of side effects,
- you would like to have “data for the future” with the possibility of later reinterpretation as scientific knowledge evolves.
How it works (home self-collection)
- Order the kit and perform a simple finger-prick blood self-collection at home according to the instructions.
- Register the sample and request form in the portal and send them back to the laboratory in the provided packaging.
- In the laboratory, DNA isolation, sequencing, and bioinformatic analysis including quality control are carried out. The standard processing time is approximately 20–30 working days from delivery of the sample to the laboratory.
- You will receive the result electronically as a clear report (PDF) in the secure results portal.
- In case of pathological findings, we offer confirmatory testing in an accredited genetic laboratory and follow-up consultation with a medical geneticist, who will recommend further preventive examinations and interventions.
What you will learn from the test
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Health predispositions (clinically significant findings)
Focused on pathogenic or likely pathogenic variants in selected genes with well-described clinical impact.
What the result report includes
The report usually contains:
- an overview of clinically significant genetic findings, if present in the sample,
- a brief interpretation of what the finding may mean and the usual recommended next steps (e.g., specialist consultation, confirmatory testing),
- for extended variants, also pharmacogenetic information for selected medications (with a reminder that treatment decisions are always the responsibility of a physician).
Important information
- A positive finding is not a diagnosis. It indicates an increased risk or predisposition – further steps should be discussed with a physician (general practitioner, specialist, or medical geneticist).
- A negative result does not exclude a genetic cause or future disease. Every genetic test has its limitations, and not all variants can currently be reliably interpreted.
- WGS may also reveal incidental findings. The scope of reported information is governed by the service settings and informed consent.
- Genetic data are sensitive. Results are provided through a secure portal; personal data processing complies with GDPR and internal security policies. Data are stored on secure servers with ISO 27001 certification.
If a clinically significant variant is detected, we can help arrange confirmatory testing and consultation in medical genetics and recommend appropriate follow-up care.
Note: This test is for informational purposes and does not replace a medical examination or clinical diagnosis. If you have health concerns or a significant family history, we recommend always consulting a physician.